ANALYSIS OF THE CELLULAR BASIS OF MORPHOGENESIS IN VERTEBRATES (CELMOVES; BFU2015-70193-REDT)

Understanding the cellular basis of morphogenesis in animal development is a current challenge in basic Biology. Advances in this area will have an important impact on understanding congenital defects and on the ability to experimentally recreate and/or regenerate organs. During embryogenesis, organs grow by cell proliferation and undergo extensive remodeling and cell reorganization to acquire the shape and tissue organization essential for their proper function. Global morphogenetic and cell reorganization events emerge from the integration of the behaviors of each single cell in the developing structures. In vertebrates, organ primordia are often composed of thousands/millions of cells and heterogeneous and interactive cellular behaviors take place across organ primodia, making the comprehensive understanding of organ formation an extraordinary challenge. Undertaking this analysis involves new developments in a diversity of areas not frequently met in a single laboratory and therefore the coordinated effort of various laboratories greatly accelerates significant advances in the field. Here we propose to coordinate a synergic network of laboratories specialized in the various disciplines involved. The efforts of the network will be directed to the analysis of two classical mouse organogenesis models; the heart and the limb. We will coordinate activities aimed to the following objectives

OBJECTIVES

  1. Describe the cellular history of the organs by tracing cell lineages, positions and trajectories at various stages
  2. Generate descriptive 4D computer models that recreate cellular trajectories and display cell behavior parameter maps.
  3. Formulate and test through predictive mathematical model hypotheses on the driving events that trans form cell behavior in morphogenetic events
  4. Experimentally test succesful hypotheses in embryos. To achieve these goals, the proposed networking will bring together experts in Embryology, Optics, Data Analysis, Biophysics and Mathematical Modelling

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Marta Ramón

mramon@cnic.es

Assistant to Miguel Torres

CNIC

Tel 914531200 ext. 3311

 

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